Virtual mitochondrion: towards an integrated model of oxidative phosphorylation complexes and beyond.

نویسندگان

Jean-Pierre Mazat

Jonathan Fromentin

Margit Heiske

Christine Nazaret

Stéphane Ransac

چکیده

The modelling of OXPHOS (oxidative phosphorylation) in order to integrate all kinetic and thermodynamic aspects of chemiosmotic theory has a long history. We briefly review this history and show how new ways of modelling are required to integrate a local model of the individual respiratory complexes into a global model of OXPHOS and, beyond that, into a reliable overall model of central metabolism.

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